Publications

2016

Robert, J.A., Bonnett, T., Pitt, C., Spooner, L.J., Fraser, J., Yuen, M.M.S., Keeling, C.I., Bohlmann, J. Huber, D.P.W. (2016) Gene expression analysis of overwintering mountain pine beetle larvae suggests multiple systems involved in overwintering stress, cold hardiness, and preparation for spring development. PeerJ 4:e2109. doi>

Keeling, C. I. (2016) Bark beetle research in the post-genomic era. Advances in Insect Physiology 50:265–293. doi>

Keeling, C. I., Li, M., Sandhu, H. K., Henderson, H., Yuen, M. M. S., Bohlmann, J. (2016) Quantitative metabolome, proteome and transcriptome analysis of midgut and fat body tissues in the mountain pine beetle, Dendroctonus ponderosae Hopkins, and insights into pheromone biosynthesis. Insect Biochemistry and Molecular Biology 70:170-183. doi>

2015

Warren, R.*, Keeling, C. I.*, Yuen, M. M. S., Raymond, A., Taylor, G. A., Vandervalk, B. P., Mohamadi, H., Paulino, D., Chiu, R., Jackman, S. D., Robertson, G., Yang, C., Hoffmann, M., Weigel, D., Nelson, D. R., Ritland, C., Isabel, N., Jaquish, B., Yanchuk, A., Bousquet, J., Jones, S. J. M., MacKay, J., Birol, I., Bohlmann, J. (2015) Improved white spruce (Picea glauca) genome assemblies and annotation of large gene families of conifer terpenoid and phenolic defense metabolism. The Plant Journal 83:189–212. doi> (*co-first authors)

2014

De La Torre, A., Birol, I., Bousquet, J., Ingvarsson, P., Jansson, S., Jones, S.J.M., Keeling, C.I., MacKay, J., Nilsson, O., Ritland, K., Street, N., Yanchuk, A., Zerbe, P., Bohlmann, J. (2014). Insights into conifer giga-genomes. Plant Physiology 166(4):1724-1732. doi>

Pitt, C., Robert, J.A., Bonnett, T.R., Keeling, C.I., Bohlmann, J., Huber, D.P.W. (2014). Proteomics indicators of the rapidly shifting physiology from whole mountain pine beetle, Dendroctonus ponderosae (Coleoptera: Curculionidae), adults during early host colonization. PLoS ONE 9(10): e110673. doi>

Janes, J.K., Li, Y., Keeling, C.I., Yuen, M.M.S., Boone, C.K., Cooke, J.E.K., Bohlmann, J., Huber, D.P.W., Murray, B.W., Coltman, D.W., Sperling, F.A.H. (2014) How the mountain pine beetle (Dendrocotonus ponderosae) breached the Canadian Rockies. Mol. Biol. Evol. 31(7):1803-1815. doi>

2013

Keeling, C. I., Chiu, C. C., Aw, T., Li, M., Henderson, H., Tittiger, C., Weng, H.- B., Blomquist, G. J., Bohlmann, J. (2013) Frontalin pheromone biosynthesis in the mountain pine beetle, Dendroctonus ponderosae, and the role of isoprenyl diphosphate synthases. Proc. Natl. Acad. Sci. USA 110(47):18838–18843. doi>

Keeling, C. I., Henderson, H., Li, M., Dullat, H. K., Ohnishi, T., Bohlmann, J. (2013). CYP345E2, an antenna-specific cytochrome P450 from the mountain pine beetle, Dendroctonus ponderosae Hopkins, catalyses the oxidative degradation of pine host odorants. Ins. Biochem. Mol. Biol. 43(12):1142-1151. doi>

Robert, J. A., Pitt, C., Bonnett, T., Yuen, M. M. S., Keeling, C. I., Bohlmann, J., Huber, D. P. W. (2013) Disentangling detoxification: Gene expression analysis of feeding mountain pine beetle illuminates molecular-level host chemical defense detoxification mechanisms.  PLoS ONE 8(11): e77777. doi>

Diaz-Chavez, M. L., Moniodis, J., Madilao, L. L., Jancsik, S., Keeling, C. I., Barbour, E. L., Ghisalberti, E. L., Plummer, J. A., Jones, C. G., Bohlmann, J. (2013) Biosynthesis of sandalwood oil: Santalum album CYP76F cytochromes P450 produce santalols and bergamotol.  PLoS ONE 10.1371/journal.pone.0075053. doi>

Hall, D. E., Yuen, M. M. S., Jancsik, S., Lara Quesada, A., Dullat, H. K., Li, M., Henderson, H., Arango-Velez, A., Liao, N. Y., Docking, T. R., Chan, S. K., Cooke, J. E. K., Breuil, C., Keeling, C. I., Bohlmann, J. (2013) Transcriptome resources and functional characterization of monoterpene synthases for two host species of the mountain pine beetle, lodgepole pine (Pinus contorta) and jack pine (Pinus banksiana).  BMC Plant Biology 13:80. doi>

Birol, I., Raymond, A., Jackman, S. D., Pleasance, S., Coope, R., Taylor, G. A., Yuen, M. M. S., Keeling, C. I., Brand, D., Vandervalk, B. P., Kirk, H., Pandoh, P., Moore, R. A., Zhao, Y., Mungall, A. J., Jaquish, B., Yanchuk, A., Ritland, C., Boyle, B., Bousquet, J., Ritland, K., MacKay, J., Bohlmann, J., Jones, S. J. M. (2013). Assembling the 20 Gb white spruce (Picea glauca) genome from whole-genome shotgun sequencing data. Bioinformatics 29(12):1492-1497. doi>

Keeling, C.I., Yuen, M.M.S., Liao, N.Y., Docking, T.R., Chan, S.K., Taylor, G.A., Palmquist, D.L., Jackman, S.D., Nguyen, A., Li, M., Henderson, H., Janes, J.K., Zhao, Y., Pandoh, P., Moore, R., Sperling, F.A.H., Huber, D.P.W., Birol, I., Jones, S.J.M., and Bohlmann, J. (2013). Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins, a major forest pest.  Genome Biology 14:R27. doi>

Andersson, M.N., Grosse-Wilde, E., Keeling, C.I., Bengtsson, J.M., Yuen, M.M.S., Li, M., Hillbur, Y., Bohlmann, J., Hansson, B.S., Schlyter, F. (2013). Antennal transcriptome analysis of chemosensory gene families in tree killing bark beetles, Ips typographus and Dendroctonus ponderosae (Coleoptera: Curculionidae: Scolytinae).  BMC Genomics 14:198. doi>

2012

Bonnett, T.R., Robert, J.A., Pitt, C., Fraser, J.D., Keeling, C.I., Bohlmann, J., Huber, D.P.W. (2012) Global and comparative proteomic profiling of overwintering and developing mountain pine beetle, Dendroctonus ponderosae (Coleoptera: Curculionidae), larvae.  Ins. Biochem. Mol. Biol. 42(12):890-901. doi>

Bohlmann, J., Breuil, C., Hamelin, R., Huber, D.P.W., Keeling, C.I., Murray, B.W. (2012). Using genomic data to understand the mountain pine beetle epidemic.  BC Forest Professional 19(4):12-13. link

Keeling, C.I., Henderson, H., Li, M., Yuen, M., Clark, E.L., Fraser, J.D., Huber, D.P.W., Liao, N.Y., Docking, T.R., Birol, I., Chan, S.K., Taylor, G.A., Palmquist, D., Jones, S.J.M., Bohlmann, J., (2012) Transcriptome and full-length cDNA resources for the mountain pine beetle, Dendroctonus ponderosae Hopkins, a major insect pest of pine forests. Insect Biochem. Mol. Biol. 42(8):525-536. doi>

2011

Keeling, C. I., Madilao, L. L., Zerbe, P., Dullat, H. K., and Bohlmann, J. (2011) The primary diterpene synthase products of Picea abies levopimaradiene/abietadiene synthase (PaLAS) are epimers of a thermally unstable diterpenol.  J. Biol. Chem.  286(24):21145–21153. doi>

Samarasekera, N. G., Keeling, C. I., Bohlmann, J., and Murray, B. W. (2011) Isolation and characterization of EST-derived microsatellite markers for the mountain pine beetle (Dendroctonus ponderosae Hopkins).  Mol. Ecol. Res. Perm. Gen. Res. Note 11(3):586-589. link

Keeling, C. I., Weisshaar, S., Ralph, S. G., Jancsik, S., Hamberger, B., Dullat, H. K., and Bohlmann, J. (2011) Transcriptome mining, functional characterization, and phylogeny of a large terpene synthase gene family in spruce (Picea spp.). BMC Plant Biol. 11:43. link

Hall, D., Robert, J. A., Keeling, C. I., Domanski, D., Lara Quesada, A., Jancsik, S., Kuzyk, M., Hamberger, B., Borchers, C., and Bohlmann, J. (2011) An integrated genomic, proteomic, and biochemical analysis of (+)-3-carene biosynthesis in Sitka spruce (Picea sitchensis) genotypes which are resistant or susceptible to white pine weevil. The Plant Journal 65:936–948. doi>

2010

Hesse-Orce, U., DiGuistini, S., Keeling, C. I., Wang, Y., Li, M., Henderson, H., Docking, T. R., Liao, N. Y., Robertson, G., Holt, R. A., Jones, S. J. M., Bohlmann, J., and Breuil, C. (2010) Gene discovery for the bark beetle-vectored fungal tree pathogen Grosmannia clavigera.  BMC Genomics 11:536. link

Zulak, K. G., Dullat, H. K., Keeling, C. I., Lippert, D., and Bohlmann, J. (2010) Immunofluorescence localization of levopimaradiene/abietadiene synthase in methyl jasmonate treated stems of Sitka spruce (Picea sitchensis) shows activation of diterpenoid biosynthesis in cortical and developing traumatic resin ducts. Phytochemistry 71:1695–1699. doi>

Aw, T., Schlauch, K., Keeling, C. I., Young, S., Bearfield, J. C., Blomquist, G. J., and Tittiger, C. (2010). Functional genomics of mountain pine beetle (Dendroctonus ponderosae) midguts and fat bodies. BMC Genomics 11:215.link

Keeling, C. I., Dullat, H. K., Yuen, M., Ralph, S. G., Jancsik, S., and Bohlmann, J. (2010) Identification and functional characterization of monofunctional ent-copalyl diphosphate and ent-kaurene synthases in white spruce (Picea glauca) reveal different patterns for diterpene synthase evolution for primary and secondary metabolism in gymnosperms. Plant Physiol. 152:1197-1208. doi>

2009

Hamberger, B., Hall, D., Yuen, M., Oddy, C., Hamberger, B., Keeling, C. I., Ritland, C., Ritland, K., and Bohlmann, J. (2009). Targeted isolation, sequence assembly and characterization of two white spruce (Picea glauca) BAC clones for terpenoid synthase and cytochrome P450 genes involved in conifer defence reveal insights into a conifer genome. BMC Plant Biol. 9:106. doi>

2008

Jones, C. G., Keeling, C. I., Ghisalberti, E. L., Barbour, E. L., Plummer, J. A., and Bohlmann, J. (2008). Isolation of cDNAs and functional characterisation of two multi-product terpene synthase enzymes from sandalwood, Santalum album L. Arch. Biochem. Biophys. 477(1):121-130. doi>

Bohlmann, J. and Keeling, C. I. (2008). Terpenoid Biomaterials.  The Plant Journal 54(4):656–669.  (Invited and refereed review) doi>

Keeling, C. I. and Bohlmann, J. (2008). Terpenoids in plants. Wiley Encyclopedia of Chemical Biology.  (Invited and refereed review) doi>

Keeling, C. I., Weisshaar, S., Lin, R. P. C., and Bohlmann, J. (2008). Functional plasticity of paralogous diterpene synthases involved in conifer defence. Proc. Natl. Acad. Sci. USA 105(3):1085-1090. doi>

Bearfield, J. C., Box, C. D., Keeling, C. I., Young, S., Blomquist, G. J. and Tittiger, C. (2008). Isolation, endocrine regulation and transcript distribution of a putative primary JH-responsive gene from the pine engraver, Ips pini (Coleoptera: Scolytidae). Ins. Biochem. Mol. Biol. 38(2):256-267. doi>

2007

Ginzel, M. D., Bearfield, J. C., Keeling, C. I., McCormack, C. C., Blomquist, G. J., and Tittiger, C. (2007). Antennally mediated negative feedback regulation of pheromone production in the pine engraver beetle, Ips pini. Naturwissenschaften 94:61-64. doi>

2006

Keeling, C. I., Bohlmann, J. (2006). Diterpene resin acids in conifers. Phytochemistry 67: 2415-2423. (Invited “Molecules of Interest” review) doi>

Keeling, C. I., and Bohlmann, J. (2006). Tansley Review: Genes, enzymes, and chemicals of terpenoid diversity in the constitutive and induced defence of conifers against insects and pathogens. New Phytologist 170(4):657-675.  (Invited and refereed review) doi>

Bearfield, J. C., Keeling, C. I., Young, S., Blomquist, G. J., and Tittiger, C. (2006). Isolation, endocrine regulation and mRNA distribution of the 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMG-S) gene from the pine engraver, Ips pini (Coleoptera: Scolytidae). Ins. Mol. Biol. 15(2):187-195. doi>

Keeling, C. I., Bearfield, J. C., Young, S., Blomquist, G. J., and Tittiger, C. (2006). Effects of juvenile hormone on gene expression in the pheromone-producing midgut of the pine engraver beetle, Ips pini. Ins. Mol. Biol.15(2):207-216. doi>

Ro, D.-K., Ehlting, J., Keeling, C. I., Lin, R., Mattheus, N. and Bohlmann, J. (2006). Microarray expression profiling and functional characterization of AtTPS genes: Duplicated Arabidopsis thaliana sesquiterpene synthase genes At4g13280 and At4g13300 encode root-specific and wound-inducible (Z)-γ-bisabolene synthases. Arch. Biochem. Biophys. 448(1-2):104-116. doi>

2005

Keeling, C. I., and Slessor, K. N. (2005). A scientific note on the aliphatic esters in queen honey bees. Apidologie 36:559-560. doi>

Tittiger, C., Keeling, C. I., and Blomquist, G. J. (2005). Some insights into the remarkable metabolism of the bark beetle midgut, in Chemical Ecology and Phytochemistry of Forest Ecosystems, ed Romeo, J. Recent Advances in Phytochemistry (Elsevier Science, Toronto), Vol. 3957-78. 2005RAP.pdf

2004

Keeling, C. I., Plettner, E., and Slessor, K. N. (2004). Hymenopteran Semiochemicals, in The Chemistry of Pheromones and Other Semiochemicals I, ed. Schulz, S. Topics in Current Chemistry (Springer-Verlag, Heidelberg) Vol. 239, 133-177. doi>

Keeling, C. I., Blomquist, G. J., and Tittiger, C. (2004). Coordinated gene expression for pheromone biosynthesis in the pine engraver beetle, Ips pini (Coleoptera: Scolytidae). Naturwissenschaften 91:324-328. doi>

2003

Eigenheer, A., Keeling, C. I., Young, S., and Tittiger, C. (2003). Comparison of gene representation in the midguts from two phytophagous insects, Bombyx mori and Ips pini, using expressed sequence tags. Gene 316:127-136.doi>

Hoover, S. E. R., Keeling, C. I., Winston, M. L., and Slessor, K. N. (2003). The effect of queen pheromones on worker honey bee ovary development. Naturwissenschaften 90:477-480. doi>

Keeling, C. I., Slessor, K. N., Higo, H. A., and Winston, M. L. (2003). New components of the honey bee (Apis mellifera L.) queen retinue pheromone. Proc. Natl. Acad. Sci. USA 100(8):4486-4491. doi>

2001

Keeling, C. I., Otis, G. W., Hadisoesilo, S., and Slessor, K. N. (2001). Mandibular gland component analysis in the head extracts of Apis cerana and Apis nigrocinctaApidologie 32:243-252. doi>

Ledoux, M. N., Winston, M. L., Higo, H., Keeling, C. I., Slessor, K. N., and LeConte, Y. (2001). Queen and pheromonal factors influencing comb construction by simulated honey bee (Apis mellifera L.) swarms. Insectes Sociaux 42:14-20. doi>

Keeling, C. I., Ngo, H. T., Benusic, K. D., and Slessor, K. N. (2001). Preparative chiral liquid chromatography for enantiomeric separation of pheromones. J. Chem. Ecol. 27(3):487-497. doi>

Keeling, C. I. and Nelson, D. E. (2001). Changes in the intramolecular stable carbon isotope ratios with age of the European cave bear (Ursus spelaeus). Oecologia 127(4):495-500. doi>

2000

Lindgren, B. S., Hoover, S. E. R., MacIsaac, A. M., Keeling, C. I., and Slessor, K. N. (2000). Lineatin enantiomer preference, flight periods, and effect of pheromone concentration and trap length on three sympatric species of Trypodendron (Coleoptera: Scolytidae).  Can. Entomol. 132(6):877-887. 2000CanEntomol.pdf

Hoover, S. E. R., Lindgren, B. S., Keeling, C. I., and Slessor, K. N. (2000). Enantiomer preference of Trypodendron lineatum (Olivier)(Coleoptera: Scolytidae), and effect of pheromone dose and trap length on its response to lineatin-baited traps in interior British Columbia.  J. Chem. Ecol. 26(3):667-677. doi>

Keeling, C. I., Koeniger, G., Koeniger, N., Slessor, K. N., and Punchihewa, R. W. K. (2000). Quantitative analysis of the mandibular gland components of the dwarf honey bee (Apis florea Fabricius).  Apidologie 31(2):293-299. (Invited Paper) doi>

1999

Keeling, C. I., Nelson, D. E. and Slessor, K. N. (1999). Stable carbon isotope measurements of the carboxyl carbons in bone collagen.  Archaeometry 41(1):151-164. doi>

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